Tranexamic acid (1197-18-8)
Nkọwa ngwaahịa
● Tranexamic acid (1197-18-8)
● CAS No.:·1197-18-8
● EINECS Nọmba: 356.2222
● MF: C8H15NO2
● ngwugwu: 25Kg/Drum
● Tranexamic acid (TXA) bụ ọgwụ a na-eji agwọ ma ọ bụ gbochie oke ọbara ịwụfu site na nnukwu trauma, ọbara ọgbụgba mgbe ọmụmụ nwa, ịwa ahụ, iwepụ ezé, ọbara imi, na nsọ nsọ.[2][3]A na-ejikwa ya maka angioedema ketara eketa.[2][4]A na-ewere ya n'ọnụ ma ọ bụ n'ibe n'ime akwara.
Usoro nke ime ihe
Tranexamic acid bụ analọg sịntetik nke amino acid lysine.Ọ na-eje ozi dị ka antifibrinolytic site na-atụgharị na-ejikọta saịtị anọ na ise lysine na plasminogen.Nke a na-ebelata ngbanwe nke plasminogen ka ọ bụrụ plasmin, na-egbochi mmebi fibrin na ichekwa usoro nke matrix fibrin. Tranexamic acid nwere ihe dị ka ugboro asatọ ọrụ antifibrinolytic nke analog ochie, ε-aminocaproic acid. ọrụ nke plasmin nwere ike na-adịghị ike (IC50 = 87 mM), na ọ nwere ike igbochi ebe ọrụ nke urokinase plasminogen activator (uPA) nwere nkọwa dị elu (Ki = 2 mM), otu n'ime ndị kasị elu n'etiti serine proteases niile.
Tranexamic acid na-arụ ọrụ
A na-ejikarị tranexamic acid na-eso nnukwu trauma.[13]A na-eji Tranexamic acid egbochi ma na-agwọ mfu ọbara n'ọnọdụ dị iche iche, dị ka usoro eze, ọbara ọgbụgba dị ukwuu, na ịwa ahụ nwere nnukwu ihe ize ndụ nke mfu ọbara.
| Ihe Nnwale | Usoro ọgwụ ọgwụ | Nsonaazụ ule | |
| ÀMÀ | Ọdịdị: White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, ntụ ntụ crystalline | White crystalline ntụ ntụ | |
| Solubility: Solubility soluble n'ime mmiri na n'ime glacial acetic acid, ihe fọrọ nke nta ka ọ ghara ịsacha ya na acetone na na ethanol (96%) | Gafe | ||
| Nchọpụta | Spectrophotometry absorption infrared: ụdịdị ụdịdị IR dakọtara na Tranexamic acid CRS | Gafe | |
| Nnwale | pH (2,2.3) | 7.0-8.0 | 7.4 |
| Ihe ndị emetụtara (HPLC2.2.29) | adịghị ọcha A≤ 0.1% | Achọpụtaghị | |
| adịghị ọcha B≤ 0.2% | 0.03% | ||
| Ihe ndị na-adịghị ọchaC Ihe adịghị ọcha na-akọwapụtaghị≤ 0.10% adịghị ọcha D Ihe adịghị ọcha ndị ọzọ | 0.002% 0.001% Achọpụtaghị | ||
| Ngụkọta adịghị ọcha na-akọwapụtaghị 0.2% | 0.003% | ||
| Halides gosipụtara dị ka chlorides | ≤140ppm | <140ppm | |
| Ọnwụ na ihicha | ≤0.5% | 0.026% | |
| Sulfated Ash | ≤0.1% | 0.027% | |
| ASSAY | Kwesịrị ịdị n'ime (nke akpọnwụwo) 99.0% 〜101.0% | 100.1% | |
