Ceftiofur Hydrochloride (103980-44-5)
Nkọwa ngwaahịa
Ceftiofur bụ ọgwụ nje nke ụdị cephalosporin (ọgbọ nke atọ), nyere ikike maka iji ya na ọgwụ anụmanụ.A kọwara ya nke mbụ na 1987.
Ọ na-eguzogide ọgwụ nje na-eguzogide enzyme beta-lactamase, ma nwee ọrụ megide nje bacteria gram-positive na gram-negative.A kọwo ụdị E. coli na-eguzogide ceftiofur.
Ceftiofur Hydrochloride bụ nnu hydrochloride nke ceftiofur, semisynthetic, beta-lactamase-stable, sara mbara, cephalosporin ọgbọ nke atọ nwere ọrụ nje.Ceftiofur na-ejikọta ma na-egbochi protein ndị na-ejikọta penicillin (PBPs) nke dị na akpụkpọ ahụ dị n'ime nke mgbidi cell nje.PBP bụ enzymes na-etinye aka na njedebe njedebe nke ikpokọta mgbidi cell nje na imegharị mgbidi cell n'oge uto na nkewa.Mwepu nke PBPs na-egbochi njikọ njikọ nke agbụ peptidoglycan dị mkpa maka ike mgbidi cell na ike siri ike.Nke a na-ebute mbelata nke mgbidi cell nje na-akpata cell lysis.
| NGWA | Nkọwapụta | Nsonaazụ | |
| Ọdịdị | White ka Gbanyụọ-ọcha Crystalline ntụ ntụ | Kwado | |
| njirimara | Oge njide nke isi kacha elu na chromatogram nwetara na ngwọta ule dabara na nke isi elu na chromatogram nwetara na ntụ ntụ ngwọta. | Kwado | |
| Mmeghachi omume nke chloride | Kwado | ||
| Ọdịdị nke ngwọta | Ido anya | Ọdịghị ike karịa No.1 Turbidity Standard | <1 |
| Agba | Ọ bụghị ọchịchịrị ka ọkọlọtọ ọkọlọtọ Y9 | <8 | |
| Solubility | Soluble na N, N-Dimethylacetamide, ntakịrị soluble na 5% nke sodium bicarbonate na methanol. | Kwado | |
| PH | 2.0-3.0 | 2.2 | |
| Ọdịnaya Mmiri | 1.5% ~ 4.0% | 1.6% | |
| Ntụgharị anya pụrụ iche | -115°~-127° | -117° | |
| Igwe dị arọ | NMT 0.0020% | Kwado | |
| Ihe fọdụrụ nke mgbanye | NMT 0.20% | 0.15% | |
| Ihe ndị metụtara ya | Nnukwu adịghị ọcha | NMT 0.20% | 0.09 |
| Mgbakọta adịghị ọcha | NMT 1.50% | 0.38 | |
| Ihe mgbaze ndị fọdụrụ | Ethyl acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0,006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0,0001 | |
| Nyocha | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Chloride | 6.0% ~ 6.5% | 6.2% | |
| Endotoxin nke nje bacteria | Ihe na-erughị 0.20EU/mg | Kwado | |
| Ịgba nwa | Na-akwado ule ahụ | Kwado | |
| Nha urughuru | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| NKWUBIOKWU | Nsonaazụ ule a dabara na nkọwapụta ahụ | ||
